A non-protective T helper 1 response against the intra-macrophage protozoan Theileria annulata
نویسندگان
چکیده
منابع مشابه
Engineering Attenuated Virulence of a Theileria annulata–Infected Macrophage
Live attenuated vaccines are used to combat tropical theileriosis in North Africa, the Middle East, India, and China. The attenuation process is empirical and occurs only after many months, sometimes years, of in vitro culture of virulent clinical isolates. During this extensive culturing, attenuated lines lose their vaccine potential. To circumvent this we engineered the rapid ablation of the ...
متن کاملApproaches to vaccination against Theileria parva and Theileria annulata
Despite having different cell tropism, the pathogenesis and immunobiology of the diseases caused by Theileria parva and Theileria annulata are remarkably similar. Live vaccines have been available for both parasites for over 40 years, but although they provide strong protection, practical disadvantages have limited their widespread application. Efforts to develop alternative vaccines using defi...
متن کاملThe protozoan parasite, Theileria annulata, induces a distinct acute phase protein response in cattle that is associated with pathology.
Acute phase proteins (APP) are synthesised in the liver in response to the systemic presence of high levels of pro-inflammatory cytokines. Bacteria are considered to be strong inducers of APP whereas viruses are weak or non-inducers of APP. Very few reports have been published on APP induction by parasites. Here, we report that the tick-borne protozoan parasite of cattle, Theileria annulata, in...
متن کاملDifferences between B cell and macrophage transformation by the bovine parasite, Theileria annulata: a clonal approach.
Theileria annulata, a tick-transmitted protozoan parasite, infects and transforms cells of the hemopoietic system, particularly those of the B cell and monocyte/macrophage lineages. Here, the effect of infection/transformation on the resulting phenotype was studied using a clonal approach. Three phenotypes of transformed cell lines could be discerned. The first is characterized by surface expre...
متن کاملProteomic analysis of the Theileria annulata schizont
The apicomplexan parasite, Theileria annulata, is the causative agent of tropical theileriosis, a devastating lymphoproliferative disease of cattle. The schizont stage transforms bovine leukocytes and provides an intriguing model to study host/pathogen interactions. The genome of T. annulata has been sequenced and transcriptomic data are rapidly accumulating. In contrast, little is known about ...
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ژورنال
عنوان ژورنال: Clinical & Experimental Immunology
سال: 1997
ISSN: 0009-9104
DOI: 10.1046/j.1365-2249.1997.3861290.x